Veterinarians

We work as a team with each pet’s primary care veterinarian and stay in touch throughout a patient’s entire treatment protocol.

SUBMIT A REFERRAL

To refer a client to our practice, please use our online referral portal.

Access The VCC Referral Portal

Clinical Trials

Clinical Trials

TANOVEA®-CA1 (rabacfosadine for injection) is the first and only FDA conditionally-approved drug for the treatment of lymphoma in dogs. This pivotal study, conducted by VetDC, Inc., is intended to provide the data to demonstrate substantial evidence of effectiveness as well as additional safety information in support of full FDA approval.

Trial Eligibility
VC-014 is a randomized, multi-center, double-blinded, placebo-controlled study evaluating TANOVEA®-CA1 (rabacfosadine for injection) administered every three weeks for up to five treatments in dogs with lymphoma (either previously treated or untreated).

Inclusion/Exclusion Criteria
In order to participate in the study, dogs must meet eligibility criteria described in the protocol. Please contact the study coordinator listed below.

Owner Incentives
The study is fully funded by the Sponsor, and owners will be offered a clinic credit towards additional treatment in the event of disease progression.

Contact Information
Deborah Bascombe, LVT
(203) 838-6626

STUDY OBJECTIVE

This trial is evaluating a cancer vaccine strategy for EGFR and/or HER2 bearing tumors in dogs. This stage of the project is simply to determine if anti-tumor antibodies arise in vaccinated animals. The vaccine is composed of a short peptide of canine EGFR (15 amino acids) mixed with LymeVax(R) (Zoetis) and mineral oil. The patient gets two 0.5 cc vaccines (SC in the nape of the neck) separated by 3 weeks regardless of the size of the dog. Blood samples will be taken at the time of the first injection (Day 0), Day 21

(time of the booster injection), Day 28 (+/- 3 -4 days) and Day 56 (+/- 7 days). Based upon mouse studies, we expect no untoward effects or even injection site reactions. There are NO contraindications with other forms of therapy, either surgical or chemotherapy. We would prefer mammary tumors and osteosarcomas (and other tumors that are presumed to express EGFR and /or HER2).

ELIGIBILITY REQUIREMENTS
  • Any dog with confirmed mammary cancer or osteosarcoma
  • Dogs with any other confirmed cancer may be eligible depending upon enrollment
  • No steroids given within 7 days
  • Performance score of 0, 1, or 2-expected survival time of over 6 weeks
EXCLUSION CRITERIA
  • Dogs less than 3 kg in body weight
  • Prior steroid use
  • Other clinical findings precluding the use of a vaccine
COMPENSATION

This is a partially funded trial. The vaccine and blood draws at the Veterinary Care Center will be at no cost to the client. The client is responsible for all other costs.

STUDY OBJECTIVE

One Health discovers tumor mutations at a DNA level to provide veterinarians with personalized cancer treatments for each dog’s unique cancer. Since cancer is a disease of genetic mutations it is critical to understand the underlying mutations driving your dog’s cancer to have the most informed treatment path. This is a pilot study.

STUDY OBJECTIVE:

The University of Pennsylvania’s Canine osteosarcoma vaccine with a live listeria vector is now being offered as part of an exciting clinical trial. This is a partially-funded trial once the pet is screened and is accepted into the trial. Dogs will receive one vaccine every 3-4 weeks for 3 cycles. Dogs will be required to stay in our hospital to be monitored for 6 hours after each vaccination.

ELIGIBILITY REQUIREMENTS:
  • Client owned dog >1 year of age
  • Body weight ≥ 2kg
  • Histopathological diagnosis of osteosarcoma
  • Undergone amputation of the affected limb followed by 4-6 doses of carboplatin (given every 2-4 weeks)
  • Free of pulmonary metastatic disease, as evidenced by radiographs at the time of screening
  • Performance score of 0 or 1
EXCLUSION CRITERIA:
  • Clinically relevant abnormalities on CBC/CS/UA
  • Evidence of pulmonary metastases on 3-view thoracic radiographs
  • Prior immunotherapy
  • Any uncontrolled medical condition (including other concurrent malignancy) that may be disruptive to theintent or objectives of the study
  • Dog is pregnant or is likely to become pregnant
  • Dog is participating in another study
  • Dog may not be available for the entire study duration
OWNER INCENTIVES:

Partially-Funded Trial

ELIGIBILITY:

This will be confirmed by reviewing the dog’s medical history, performing a physical exam, taking thoracic radiographs, and submitting routine blood and urine tests. All dogs enrolled in the safety study will be treated with COV-LLV.

STUDY OBJECTIVE

The primary objective of this study is to determine the maximum tolerated dose, dose-limiting toxicities, safe starting dose, and pharmacodynamic effect of TANOVEA™ (Rabacfosadine for injection) in cats with lymphoma, lymphoid leukemia or multiple myeloma/plasma cell tumor. A secondary objective of this study is to assess the efficacy and determine progression-free survival in treated cats.

INCLUSION CRITERIA

Species: Feline

Breed: No specification

Initial age: At least 1 year old on Day 0

Weight: No weight requirement

Sex: Male or female, intact or neutered

Origin: Client–owned cats

Diagnosis: Cats must have a diagnosis of low, intermediate or high grade, lymphocytic or lymphoblastic lymphoma, cytologically or histologically confirmed in any anatomic site.

Prior treatment: Prior surgery, radiotherapy, and/or chemotherapy are acceptable. There must be a two-week washout period between prior chemotherapy and Day 0 and a six-week washout period between radiotherapy and Day 0.

General health: Cats must be free of severe underlying disease (including underlying pulmonary pathology), be FeLV, and FIV negative, and have an expected survival of at least 6 weeks. Cats must have adequate organ function as indicated by standard laboratory tests: (hematology [CBC], clinical chemistry [CC] and urinalysis [UA]). Specifically, cats must have:

  • Absolute neutrophil count > 1,500 cells/μL
  • Hematocrit > 25%
  • Platelet count > 100,000/μL
  • Serum creatinine < 2.5 mg/dL
  • Bilirubin ≤ the upper normal limit
  • Transaminases ≤ 3 times the upper normal limit or if > 3
  • times the upper normal limit then serum bile acids must
  • be ≤ the upper normal limit
  • The animal must have a performance status of < 1 on
  • Day 0, according to the modified ECOG Performance
  • Scheme (Veterinary and Comparative Oncology, 2010).
EXCLUSION CRITERIA
  • Cats that have received chemotherapy within 2 weeks of Day 0.
  • Cats that have received non-steroidal anti-inflammatory drugs (NSAIDS) within 72 hours of Day 0. While on study, treatment with prednisone (1 mg/kg every other day) is acceptable.
  • Cats that have received radiation therapy within 6 weeks of Day 0.
  • Concurrent malignancy or other serious systemic disorder incompatible with this study.
OWNER INCENTIVES
  • TANOVEA™ (Rabacfosadine for Injection) is provided at no cost for use in this study.
  • $1,500 client incentive for each cat enrolled, to be used for treatment costs.
  • In the event of AE-related hospitalization costs as a result of participation in the study, up to $3,000 per cat to cover clinical trial-related hospitalization costs. This will be addressed on a case-by-case basis.
  • Client is responsible for all other charges.

Trial Specifics

This trial is designed to evaluate the safety and preliminary pain management and anti-cancer effectiveness of a novel therapy in dogs with bladder transitional cell carcinoma (TCC). The trial involves one-time procedure administered directly into the bladder using a urinary catheter. Dogs may receive a second infusion one month after enrollment if warranted.  The infusion will be administered under sedation or general anesthesia. There is no placebo in this trial.  An estimated 15 client-owned dogs with will be enrolled.  Owners will be required to complete quality of life surveys, collect a daily urine sample for visual analysis, and record the urine collection results in a provided journal. The trial site will train the owners on collection and evaluation techniques. Trial visits include the dog’s initial consultation, day of administration (Day 0), and then recheck visits on Days 7, 14, 28, 56, and 84.Anti-cancer therapies must be discontinued 21 days prior to enrollment. Medications targeted at the treatment of TCC-associated pain, except for CBD and other cannabinoids, are acceptable provided they have been administered for at least 2 weeks prior to enrolling in the study.

Trial Funding

The trial is fully funded for the full trial duration (84 days).  Funding includes the initial consultation, the study investigational agent and administration, thoracic radiographs at the beginning and end of the study, monthly abdominal ultrasounds, recheck visits, trial-required bloodwork, and management of side effects that are thought to be directly related to the trial.

Trial Eligibility

Trained veterinarians at the trial sites will evaluate each dog for eligibility.

Dogs are eligible if they meet the following inclusion criteria:

  • Dog presenting with a diagnosis of TCC exclusively associated with the bladder (metastasis is acceptable).
  • Dog with accompanying lower urinary tract clinical signs associated with bladder cancer.
  • Bladder lesion does not prevent the passage of urinary catheter.

Dogs are not eligible if they meet any of the following exclusion criteria:

  • Dog with urethral involvement of TCC.
  • Dog has any underlying disease that will affect the study objectives or patient safety.
  • Dog has evidence of hydronephrosis.
  • Dog has an active urinary tract infection (dogs presenting for screening will have a urine culture performed prior to enrollment).
  • Dog has a urethral obstruction.
  • Dog is pregnant or lactating.
  • Dog is participating in another study.

Contact us to learn more about our ongoing clinical trials and how they might benefit your patients.

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TUMOR STAGING

We support our referring veterinarians doing tumor staging prior to referring a patient to us for care. Please contact us for a free consultation so we can explain what diagnostics we require and how we would like them performed for the greatest accuracy.

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Continuing EDUCATION

As part of our ongoing commitment to veterinary education and research, The Veterinary Care Center (The VCC) holds an annual continuing education seminar. The seminar is accredited through the Registry of Approved Continuing Education (RACE). In addition we are excited to share that we are in the process of putting together a continuing education series for veterinary technicians.

We all work hard and that sometimes means we do not always having enough time to relax and have fun. For that reason The VCC also comes up with unique and innovative ways for veterinarians and their staff, to connect on a personal level. Check back regularly to see upcoming events and activities.

View Continuing Education Events

LUNCH & LEARNS

Trying to work, eat lunch, and keep up on the latest in CE can be a challenge. Let us help! You pick the topic; we’ll bring lunch and the speaker. Choose from the following speakers and topics.

Gerald Post

DVM, MEM, DACVIM (Oncology)

Cancer Update: What’s on the Horizon for Veterinary Oncology?
TANOVEA: A New Drug for Lymphoma
Osteosarcoma: Multi-Modality Therapy
Working Up Mast Cell Tumors: How to Demystify the Process
Lymphomas: Does the Sub-Type Really Matter?

Kevin Ware

DVM, DACVR-RO (Radiation Oncology)

Post-Operative Radiation Therapy for Skin Tumors
Benefits & Misconceptions of Palliative Radiation Therapy
Imaging for Prospective Oncologic Patients

All lectures last approximately 60 minutes. Interested in a topic not listed? Just ask!

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YOUR RRM AT THE VCC

What is a Referral Relationship Manager

As your liaison to The VCC, Kimberly will help you offer the best possible, state-of-the-art care to your patients. She is your link to us and is dedicated to building ongoing, trustworthy relationships between you and our team.

How We Can Help

Kimberly can set you and your team up with resources that will help your hospital provide the best care when your patients and their families are faced with a difficult diagnosis.

  • Resources to help your technicians receive more training
  • On-site continuing education with one of our doctors or technicians
  • Answers to questions about referral reports

Kimberly Knapp

Kimberly originally hails from the Washington DC area and is a graduate of George Mason University with a Bachelor’s Degree in Public Relations and Communications. Her love for veterinary medicine developed at an early age, when she began working as a veterinary assistant and receptionist in high school. Kimberly’s passion for the field led her to pursue her veterinary technician education and she became a Certified Veterinary Technician in 2008. Kimberly has also been a hospital manager and head technician at an AAHA accredited practice for 11 years. In her personal time, she enjoys travel, competing in triathlons, and hiking with her husband and their two rescue dogs, Luke and Seaver. Kimberly’s goal at The VCC is to spread our message of hope and compassionate care for our patients and their pet parents.