The University of Pennsylvania's Canine osteosarcoma vaccine with a live listeria vector is now being offered as part of an exciting clinical trial. This is a fully funded trial once the pet is screened and is accepted into the trial.
Dogs will receive one vaccine every 3-4 weeks for 3 cycles. Dogs will be required to stay in our hospital to be monitored for 6 hours after each vaccination.
- Client owned dog >1 year of age
- Body weight ≥ 2kg
- Histopathological diagnosis of osteosarcoma
- Undergone amputation of the affected limb followed by 4-6 doses of carboplatin (given every 2-4 weeks)
- Free of pulmonary metastatic disease, as evidenced by radiographs at the time of screening
- Performance score of 0 or 1
- Clinically relevant abnormalities on CBC/CS/UA
- Evidence of pulmonary metastases on 3-view thoracic radiographs
- Prior immunotherapy
- Any uncontrolled medical condition (including other concurrent malignancy) that may be disruptive to the intent or objectives of the study
- Dog is pregnant or is likely to become pregnant
- Dog is participating in another study
- Dog may not be available for the entire study duration
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